Dimethyl malonate is a crucial organic synthesis intermediate. It is a colorless liquid obtained by esterifying dimethyl malonate with methanol. Widely used in pharmaceuticals, dyes, and fragrances, it is commonly employed in synthesizing barbiturates (such as barbituric acid) and the key pharmaceutical raw material piperazine. It exhibits high chemical reactivity, participating in diverse reactions including hydrolysis, decarboxylation, and alkylation, making it a versatile reagent in organic synthesis.
| Chemical Name | Dimethyl Malonate |
| Chemical Formula | C5H8O4 |
| CAS | 108-59-8 |
| Appearance | Colorless liquid |
| Melting point | -62ºC |
| Boiling point | 180-181 °C |
| Density（ρ20）, g/cm³ | 1.156 g/mL at 25 °C |
| Molecular Weight | 132.11 |
| Solubility | Soluble in organic solvents such as alcohol and ether; slightly soluble in water. |
Used in pharmaceuticals and organic synthesis.
Dimethyl malonate is a key raw material for producing the pharmaceutical piperazine. Internationally, dimethyl malonate is primarily used as a raw material for producing pipecolic acid via the non-ethoxymethylene process, reacting with formic acid esters and urea to yield pipecolic acid. Currently, the majority of dimethyl malonate produced by relevant enterprises in China is used for pipecolic acid production, with only a portion exported.
1. Store in a cool, well-ventilated warehouse. Keep away from ignition sources and heat. Store separately from oxidizers, strong alkalis, and reducing agents; do not store together. Equip with appropriate types and quantities of firefighting equipment. The storage area should be equipped with emergency leak response equipment and suitable containment materials.
2.This product is packaged in iron drums or galvanized iron drums, each containing 200 kg. Store and transport in accordance with regulations for flammable chemicals.
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