Diethyl ethoxymethylene malonate

Diethyl ethoxymethylene malonate

Diethyl ethoxymethylene malonate

Diethyl ethylenediaminetetraacetic acid is an important organic compound frequently used as an intermediate in drug synthesis, particularly for manufacturing drugs such as norfloxacin, chloroquine, and lomefloxacin. It is a colorless, transparent, viscous liquid obtained by the condensation reaction of diethyl malonate with triethyl orthoformate followed by de-ethanolation. As a key raw material in the pharmaceutical and pesticide industries, it plays a vital role in these sectors.

Typical Properties

Chemical Name Diethyl ethoxymethylene malonate
Chemical Formula C10H16O5
CAS 87-13-8
Appearance Colorless liquid
Melting point -33°C
Boiling point 279-281℃
Density(ρ20), g/cm³ 1.080 g/mL at 20 °C
Molecular Weight 216.23
Solubility Insoluble in water

Application

An important organic raw material containing multiple active functional groups in a single molecule, capable of undergoing polycondensation and cyclization reactions with various substances. It is widely used in the synthesis of pharmaceuticals, pesticides, and additives, serving as an intermediate in the production of chloroquine, norfloxacin, and lomefloxacin.

Storage Instructions

Storage Instructions

This product is packaged in plastic drums or double-walled drums with plastic liners. During transportation, take precautions against violent shaking, moisture, rain, and direct sunlight. Store in a dry, cool warehouse; avoid outdoor stacking. Keep away from heat sources and open flames; store in a cool place.

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